Statin Intolerance: Diagnosis and Remedies

Abstract Despite the efficacy of statins in reducing cardiovascular events in both primary and secondary prevention, the adherence to statin therapy is not optimal, mainly due to the occurrence of muscular adverse effects. Several risk factors may concur to the development of statin-induced myotoxicity, including patient-related factors (age, sex, and race), statin properties (dose, …

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Ten-Year Follow-up After Initiation of Statin Therapy in ChildrenWith Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is a prevalent (1:500 individuals) inherited disorder that strongly predisposes to premature atherosclerosisandsubsequent cardiovascular disease. In children with FH, atherosclerosis progression is observed before puberty. Consequently, guidelines for FH treatment advocate initiation of statins in childrenasyoung as8 years. However, longterm efficacy and safety data for statin therapy initiated during childhood do not exist.We …

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Therapeutic algorithm for Patients with severe Hypercholesterolemia or isolated Lipoprotein(a)-Hyperlipoproteinemia with progressive cardiovascular disease: PCSK9-Inhibitors, Lipoprotein Apheresis or both?

Therapeutic algorithm for Patients with severe Hypercholesterolemia or isolated Lipoprotein(a)-Hyperlipoproteinemia with progressive cardiovascular disease: PCSK9-Inhibitors, Lipoprotein Apheresis or both? Nephrologisches Zentrum GöttingenGbR Priv. Doz. Dr.med. V. Schettler

NORMARE LA PATOLOGIA GENETICAMENTE DETERMINATA IPERLp (a)LIPOPROTEINEMIA CHE SI ASSOCIA AD ALTO RISCHIO CARDIOVASCOLARE

Giovedì 12 Maggio 2016  AUDITORIUM MINISTERO DELLA SALUTE  Lungotevere Ripa, 1  ROMA     La diffusione della malattia in Italia ed nel Lazio La prevalenza storica, rispettivamente della Ipercolesterolemia Familiare (IF) Omozigote ed Eterozigote è di 1: 1000000 e di 1:500. In Italia circa 2200 ragazzi sotto i 14 anni soffrono …

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EFFICACY OF ALIROCUMAB IN 1,191 PATIENTS WITH A WIDE SPECTRUM OF MUTATIONS IN GENES CAUSATIVE FOR FAMILIAL HYPERCHOLESTEROLEMIA

Authors: John J.P. Kastelein, Gisle Langslet, Paul Hopkins, Joep Defesche, Werner Seiz, Marie Baccara-Dinet, Sara Hamon, Poulabi Banerjee, Claudia Stefanutti, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA, Sanofi, Montpellier, France Background: Next Generation Sequencing was performed to examine treatment response with alirocumab in patients carrying one or more causative mutation(s) in five familial …

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