FCS Announcement

We are collecting anonymised information on patients with familial chylomicronaemia syndrome (FCS)/multifactorial chylomicronaemia syndrome (MCS) as a service evaluation & quality improvement project. The project aims to improve understanding of natural history of FCS and to validate the use of FCS scoring algorithm. The project is approved by Manchester University …

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15th LIPIDCLUB AND THERAPEUTIC APHERESIS

Re-scheduled September 3-4, 2020 15th LIPID CLUB AND THERAPEUTIC APHERESIS 1st JOINT MEETING WITH THE NATIONAL ASSOCIATION FOR FAMILIAL HYPERCHOLESTEROLAEMIA (A.N.I.F. Italia) TWENTY YEARS CELEBRATION Advanced Course on Clinical Lipidology, Metabolicdisorders, and atherosclerosis preventionFocus on novel drugs and therapeutic apheresis Rome, September 3-4, 2020Globus HotelViale Ippocrate, 119 – 00161 Rome …

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E-ISFA 2020 Announcement

3rd Congress of the European Group – International Society for Apheresis (E-ISFA) Dresden, March 19 to 21, 2020 Congress Topics Recent progress in lipoprotein apheresis Homozygous familial hypercholesterolemia Lipoprotein(a) Competition with drugs Plasma exchange Immunoadsorption – indications, results, future perspectives Experience with extracorporeal therapy in children and during pregnancy Apheresis Registries …

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Brochure

The brochure on Familiar Hypercholsterolemia from Nutritional Medicine Institute of Austrian Academy (in German)  Die Broschüre über familiäre Hypercholesterinämie von Österreichisches Akademisches Institut für Ernährungsmedizin (ÖAIE)

The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia – a post-hoc analysis of a Phase 3, single-arm, open-label trial.

OBJECTIVE: Lomitapide (a microsomal triglyceride transfer protein inhibitor) is an adjunctive treatment for homozygous familial hypercholesterolaemia (HoFH), a rare genetic condition characterised by elevated low-density lipoprotein-cholesterol (LDL-C), and premature, severe, accelerated atherosclerosis. Standard of care for HoFH includes lipid-lowering drugs and lipoprotein apheresis. We conducted a post-hoc analysis using data …

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The role of microparticles in inflammation and transfusion: a concise review

Abstract Microparticles are small membrane-bound vesicles, found in body fluids including peripheral blood. Microparticles are an intrinsic part of blood labile products delivered to transfused patients and have active roles in inflammation. They are delimited by a lipid bilayer composed mainly of phospholipids, cholesterol, membrane-associated proteins, intracellular components such as metabolic enzymes, proteins-involved …

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Implementing American Heart Association Pediatric and Adult Nutrition Guidelines

A Scientific Statement From the American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity and Metabolism, Council on Cardiovascular Disease in the Young, Council on Arteriosclerosis, Thrombosis and Vascular Biology, Council on Cardiovascular Nursing, Council on Epidemiology and Prevention, and Council for High Blood Pressure Research Read More

Androgen levels in women with various forms of ovarian dysfunction: associations with cardiometabolic features

Studyquestion: Are differences in androgen levels among women with various forms of ovarian dysfunction associated with cardiometabolic abnormalities? summaryanswer: Androgen levels differed substantially between women with and without ovarian dysfunction, and increased androgen levels were associated with impaired cardiometabolic features in all women irrespective of their clinical condition. what is …

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Statin Intolerance: Diagnosis and Remedies

Abstract Despite the efficacy of statins in reducing cardiovascular events in both primary and secondary prevention, the adherence to statin therapy is not optimal, mainly due to the occurrence of muscular adverse effects. Several risk factors may concur to the development of statin-induced myotoxicity, including patient-related factors (age, sex, and race), statin properties (dose, …

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Ten-Year Follow-up After Initiation of Statin Therapy in ChildrenWith Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is a prevalent (1:500 individuals) inherited disorder that strongly predisposes to premature atherosclerosisandsubsequent cardiovascular disease. In children with FH, atherosclerosis progression is observed before puberty. Consequently, guidelines for FH treatment advocate initiation of statins in childrenasyoung as8 years. However, longterm efficacy and safety data for statin therapy initiated during childhood do not exist.We …

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