Ten-Year Follow-up After Initiation of Statin Therapy in ChildrenWith Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is a prevalent (1:500 individuals)
inherited disorder that strongly predisposes to premature atherosclerosisandsubsequent cardiovascular disease. In children with FH, atherosclerosis progression is observed before puberty. Consequently, guidelines for FH treatment advocate initiation
of statins in childrenasyoung as8 years. However, longterm efficacy and safety data for statin therapy initiated during childhood do not exist.We followedup a cohort of children with FH receiving statin therapy until adulthood.

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JAMA. 2014 Sep 10;312(10):1055-7. doi: 10.1001/jama.2014.8892.

Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia.


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